The role of intracellular infection during osteomyelitis remains an active topic of research. Based on systematic reviews of the literature, peri-implantitis occurs in 20-56% of patients with dental implants, and 5% of dental implants are lost to the disease over a period of . protective biofilms or application of disinfectant, or their combination, using two commercial oral rinses, Decapinol® and Colgate Periogard®. CHI coordinates research across Stevens' four schools and in collaboration with external partners including leading hospitals, health care centers and government agencies. Phone: 801-582-1565 x 4607. Our research focuses on the genetic regulation of biofilm development using genome-wide S. aureus microarray profiling that has been recently implemented in our laboratory.. To fulfil our goals, we are currently: performing a morphological analysis of biofilm development using confocal microscopy of fluorescently-labeled S.aureus,; correlating morphologic stages with defined patterns of gene . There are 3 main foci in my laboratory: biodegradation, biofiltration, and biofilms. The laboratory is located in the Lutz Hall Building. Bld 2, RM 1C15. This so-called SWIR . Staphyloccocus aureus is one of the major pathogens in orthopedic periprosthetic joint infection (PJI), a devastating complication of total joint arthroplasty that often results in chronic and persistent infections that are refractory to antibiotics and require surgical interventions. The lab is interested in investigating the underlying molecular mechanisms by pursuing three specific areas of research. Bones and biofilms: Researchers Kathryn Grandfield, John Whitney awarded prestigious HFSP grants Engineering professor Kathryn Grandfield, seen here, has received a prestigious grant worth more than $1.3 million from the Human Frontier Science Program. Congressionally Directed Medical Research Program-Peer Reviewed Orthopaedic Research Program. Ho-Lun Wong's Lab. However, osteitis may be exacerbated by surgery and a marker of refractory disease, not a causative agent. The microbiology lab focuses on infection, analysis of biofilm formation, including intra- and extracellular microbial infections. Below is a view of the stainless steel imaged with a fluorescent confocal microscope. Beyond basic science in our state-of-the-art laboratories, departmental research extends to clinical activities through faculty . Biofilms can be described as 'a community of bacterial cells connected by their secreted extracellular matrix'. Biofilm formation has been extensively investigated as a reason for persistent infection. We design and develop advanced 3D miniaturized in vitro models mimicking different musculoskeletal tissues, including bone, cartilage, and muscle. The Allegheny Health Network Center for Excellence in Biofilm Research (AHN CEBR) is an innovative research environment. The centre's activities focus on phenomena associated with biofilms and biobarriers. The microbiology lab focuses on infection, analysis of biofilm formation, including intra- and extracellular microbial infections. Bone and Biofilm Research Lab Volunteer Paid Part Time Research Assistant: NIH Funded Study on Neural Bases of Speech Perception in Hearing Loss Seeking an Undergraduate Research Assistant for Fungal Research Symptom Care at Home-Heart Failure Gender-Based Violence Environmental justice investigation across the US The main focus of this lab is to develop and implement innovative and ground-breaking techniques for use in image-guided surgeries and the creation of non-invasive image-based diagnostic systems, which can help to revolutionize the early diagnosis of numerous diseases and brain disorders. Graduate Students The Smart Biomaterials Research Laboratory studies how biomaterials interact with the body, and it develops smart materials that enhance the treatment and diagnosis of diseases and injuries. They debate whether the tissues are real, based on laboratory-measured tissue decay rates, or whether the tissue decay rates are real, based on plainly observed tissues. The Journal of Orthopaedic Research, a publication of the Orthopaedic Research Society (ORS), is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies. Periodontitis affects up to 47% of the US population. While evaluation of biofilms in the in vitro laboratory setting is imperative to the understanding of biofilm growth mechanisms, antibiotic resistance patterns, and materials susceptibility, research has progressed to necessitate methodologies to evaluate clinical samples of suspected biofilm infections for diagnostic purposes. Research activities: I have worked in Dr. Haluk Beyenal's biofilm research lab since my freshman year, where I study the bacterium that causes citrus greening disease. . Her primary interest is focused on establishing novel strategies for eradicating Staphylococcus aureus biofilms on prosthetic joint hardware. . National Physical Activity and Biomarkers of Bone Mineral Density in Persons with I have presented my research in 2021 at WSU SURCA, earning a Crimson Award, and presented at the National Collegiate Honors College Conference in Fall 2021. The microsurgery lab is primarily used for basic sciences research. Serum or joint fluid laboratory . Our research aims to understand how bacterial pathogens interact with the host using a combination of functional genomics and single gene-level functional studies. In order to detect cholesteatomas and bacterial biofilms and to remove them safely, the new collaborative project 'BetterView' is working on a special surgical microscope. Abstract: Pseudomonas aeruginosa is a bacterial pathogen that causes several important chronic infections. The microsurgery lab is primarily used for basic sciences research. Our research focuses on the genetic regulation of biofilm development using genome-wide S. aureus microarray profiling that has been recently implemented in our laboratory.. To fulfil our goals, we are currently: performing a morphological analysis of biofilm development using confocal microscopy of fluorescently-labeled S.aureus,; correlating morphologic stages with defined patterns of gene . Our lab's research. An entirely new project for the lab is a collaboration with Dr. Dianne Newman in the Division of Geology and Planetary Science.The topic is environmental bacterial biofilms, and the goal is identify,visualize,and ultimately understand the multiple different metabolic cell states that comprise a biofilm at different stages of its development and . This demonstrates the potential of 'anti-resistance strategies' that interfere with community behaviour to enhance the longevity of conventional antibiotics. The composition of the C. acnes biofilm matrix has been explored in several in vitro studies. Microsurgery Lab. Biofilm Pharma uses its proprietary High Troughput Screening robotic platform in an unprecedented screening campaign of antimicrobial molecules with an anti-biofilm added value. Pluris Research, Inc. was established in 2001 and is located in Franklin, TN. Bone & Biofilm Research Lab Sep 2019 - Present2 years 7 months Salt Lake City, Utah, United States • Provided microbiology testing for Light Line Medical startup - designed, ran, and troubleshot. Lee's research group has developed and applied various electrochemical microsensors for environmental and biomedical research (e.g., biofilm, corrosion, plants, emulsion, and sediments) and for in situ monitoring in aqueous systems (e.g., N & P-cycle, PAHs, heavy metals). University of Utah Orthopaedic Center. Biofilms are assemblages of microorganisms that attach and grow on almost any surface with which they come in contact ().Biofilm formation follows a developmental progression consisting of four main stages: reversible attachment, irreversible attachment, growth and differentiation, and dissemination (or detachment). Quantifying the Accuracy of Biofilm Infection Models. Outside the research laboratory, biofilm detection remains difficult and specific treatment remains elusive. Research Biofilm formation is crucial for bacterial persistence and chronic infections. The blue objects are the bone cells, while the green represents the bone material (osteoid) created by the bone cells. Research Labs, Racine/Kenosha Regional Society for Clinical Laboratory Science, Kenosha, WI, 2006. . In 2016, he became the Director of the Bone and Joint Research Lab located in the Department of Veterans Affairs in Salt Lake City, UT. This technology is the only one to focus . The practical applications of the research include diagnostics, treatment methods, drug formulation and the use and development of medical . Poster/Abstract; Denver, CO (2017). The bone cells and the bone material that they created during the testing were made more easily recognizable by applying fluorescent stains. Methods: Model I consisted of the biofilm growth of Candida albicans on denture acrylic. Within bone, metastatic cancer cells highjack the normal couple process of bone remodeling, resulting in excess bone degradation and subsequent release of growth factors that . Model I involved infected bone marrow and fragments. Introduction. American Society for Bone and Mineral Research (ASBMR) Annual Meeting. Her background in chemical biology and protein biochemistry proved an asset to the lab's largely genetic approach to biofilm research and she began her postdoctoral research here in August, 2012. Introduction: Corynebacteria represent often-neglected etiological agents of post-traumatic and/or post-operative bone and joint infection (BJI). The temporal bone is a key structure in auditory processing. Min C, Park J, Mun J, Lim Y, Min J, Lim J, Kang D, Ahn H, Shin T, Cheon J, Lee H, Weissleder R, Castro CM, Lee H, Integrated microhall magnetometer to measure magnetic properties of nanoparticles, Lab on a Chip, 17(23), 4000-4007 (2017).Link. Implant-associated infections are commonly caused by biofilms. Biofilms of a C. acnes skin isolate grown in cell culture flasks contained polysaccharides, proteins and extracellular DNA (eDNA), with the polysaccharides containing α-mannopyranosyl and α-glucopyranosyl residues [ 41 ]. Since arriving in Maryland, Dr. Shirtliff continues his research and teaching interests in biofilms and was promoted to Full Professor with tenure in 2017. The centre's activities focus on phenomena associated with biofilms and biobarriers. Microsurgery Lab. Below is a view of the stainless steel imaged with a fluorescent confocal microscope. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcalabscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network (OLCN) of cortical bone. Infections may even cause removal of prosthesis or significant delay in healing. Our research aims to understand how bacterial pathogens interact with the host using a combination of functional genomics and single gene-level functional studies. Available equipment includes: CDC biofilm reactors, electrolysis equipment, cell and bacterial culture equipment. Cassat's postdoctoral research in the laboratory of Dr. Eric Skaar examined the bacterial virulence factors used by S. aureus to colonize and destroy bone. The numbers of primary total hip and knee arthroplasties have been increasing over time, with 332,000 total hip and 719,000 total knee arthroplasties performed in 2010 in the United States. The Department of Oral Biology is comprised of Faculty, Staff, PhD students and Post-doctoral fellows engaged in scholarship and research. Students will gain experience in translational research, have opportunities to publish, have outstanding letters of recommendation and receive guided mentorship. The Bone and Biofilm Research lab is looking for motivated students to join various projects focused on translational infection mitigation technology. PRL's Quality Control Department includes an advanced, state-of-the-art laboratory staffed with scientists and a sourcing team dedicated to maintaining the high quality and integrity of raw . CONTACT INFORMATION. The departmental expertise forms a foundation for many of the basic science topics taught to our DMD, MS and PhD students. Leah Cook, PhD My lab's research is focused on investigation of cellular interactions within the tumor bone microenvironment that contribute to tumor progression, with a specific focus on immune cell-tumor interactions. We also operate a Drug Discovery & Biotechnology Lab within the Center. We design and develop advanced 3D miniaturized in vitro models mimicking different musculoskeletal tissues, including bone, cartilage, and muscle. This requires the combination of multi-scale modeling, additive manufacturing, 3D printing, and experimental synthesis, which is then applied to bio-inspired . Not two weeks later, Wacker was hit by a car while riding her bicycle home from work. 3D biomaterial-based models are crucial for closing the reproducibility gap between 2D tissue culture and animal models by . Biofilms Research Center for Biointerfaces is a multidisciplinary research centre within materials and life sciences. Bone Regeneration and Infection Management using 3D Printed Scaffolds Chronic osteomyelitis (OM) is a serious clinical problem in orthopaedic surgery, as approximately 112,000 orthopaedic device-related infections occur every year in the US alone, with an estimated overage in hospital costs of $15,000-30,000 per incident. treatment remains scant when compared with the . Periodontitis is a biofilm induced chronic inflammatory disease that is characterized by gingival inflammation and alveolar bone loss around teeth. Lab Alumni. However, the use of planktonic cells has . Bone and Joint Research Lab. Drew Clearfield (Ph.D. Materials Science and Engineering 4/2018 Multizonal Scaffolds for Osteochondral Tissue Engineering) Changmin Hu (Ph.D. Materials Science 12/2017 Fabrication and Characterization of Collagen-Apatite Composites for Bone Tissue Engineering) Stephanie Bendtsen (Ph.D. Materials Science 5/2017 3D Bioprinting of Alginate Hydrogels for Bone Tissue Regeneration) Currently, the majority of animal models that are used to study biofilm-related infections utilize planktonic bacterial cells as initial inocula to produce positive signals of infection in biomaterials studies. In particular, our research aims to investigate the mechanisms underlying the metastatic process and the pathogenesis of inflammatory articular diseases, with a focus on the process of extravasation . The latest report on this subject characterized original . Electrical Stimulation of Titanium for the Prevention and/or Eradication of A. baumannii and S. aureus Biofilm Infections on Osseointegrated Prostheses. Biofilms Research Center for Biointerfaces is a multidisciplinary research centre within materials and life sciences. We are interested in understanding host-bacterial interactions that are key to persistent infections, with a focus on bacterial strategies to survive within the host, including intracellular survival and formation of biofilm . Dr. oral biosensors. Earlier. Working at the intersection of advanced materials, microbiology, medicine and sensors, the lab is developing smart materials that provide. Our current research mainly focuses on resistance development in Salmonella biofilms, in brewery biofilms and biofilms on orthopedic implants and catheters. Biomedical Engineering. Sound travels through the external auditory canal of the outer ear, to the tympanic membrane and middle ear bones of the middle ear, until it reaches the inner ear where it is translated into a neural impulse. It is composed of the outer, middle, and inner ear. Dustin and his team manage research programs that span biofilm-related infections, osseointegration, bone pathologies such as heterotopic ossification, and specialize in hard plastic embedment for histological . October 2010-October 2013. S. aureus persists as a biofilm in the bone niche during . Salt Lake City, UT 84148. In January of 2022, Paris committed to the Immunology and Microbial Pathogenesis program and joined our lab to complete her thesis research. ProfessorDepartment of Microbiology & Immunology and Department of Orthopaedics Research Interest: Molecular Pathogenesis of Staphylococcus aureus infectionsPh.D. Research Highlights. Bones and biofilms: Researchers Kathryn Grandfield, John Whitney awarded prestigious HFSP grants Engineering professor Kathryn Grandfield, seen here, has received a prestigious grant worth more than $1.3 million from the Human Frontier Science Program. 500 Foothill Dr. Mail Code: 151F. Lab Alumni. In October 2005 Bill Costerton invited a small group of established and junior biofilm researchers to a 'Biofilm Bash' in Los Angeles (CA, USA) to discuss the rapid advances that had developed in the field over the preceding decade, to think about how new and exciting technologies could be applied to biofilm research and to identify directions that the field might develop in . Jasper Zheng, M.D. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx. Salt Lake City, UT 84108. An Overview of Prosthetic Joint Infection (PJI) Definition and Diagnosis. We are an independent, private, state of the art surgical research laboratory specialized in providing pre-clinical studies for consumer-medical-surgical product research and development. Center for Biofilm Engineering Montana State University 366 Barnard Hall P.O. silviya.zustiak@slu.edu; Website Silviya Zustiak's laboratory focuses on hydrogel biomaterials and soft tissue engineering, with emphasis on developing novel biomaterials as cell scaffolds, drug screening platforms and protein delivery devices. It affects almost 50% of the population and represents a risk factor for numerous systemic conditions with underlying low-grade inflammation 1-3. to the deeper portion of the bones, the ease of biofilm formation on bone surface, and high risk of drug toxicity. Original dinosaur tissues in fossil bones are probably the most controversial finds in all of paleontology. His current research interests also include smart water and wastewater . We are dedicated to our Sponsors providing the best preclinical research support . Bone-targeted bisphosphonate-antibiotic conjugates for the treatment of osteomyelitis biofilms. Following Professor Mark Shirtliff's death on July 12, 2018, his long-term research collaborator and lab manager, Dr. Janette Harro, is continuing most of his lab . The blue objects are the bone cells, while the green represents the bone material (osteoid) created by the bone cells. Our screening is unique thanks to the use of a patented technology of the Biofilm Technologies Group : the Biofilm Ring Test®. Peri-implantitis, a disease precipitated by biofilm-producing oral pathogens, causes mucosal inflammation and progressive bone loss at the site of implantation . Lab. Broken bones in her neck and leg rendered her effectively . The oral commensal spirochete T. denticola is a major component of the complex bacterial biofilm that causes periodontitis, a chronic inflammation of the tissues and bone that support the teeth. We are interested in understanding host-bacterial interactions that are key to persistent infections, with a focus on bacterial strategies to survive within the host, including intracellular survival and formation of biofilm . . This is often due to the accumulation of microbial plaque or biofilm on implants, screws or plates, which contribute to recurrent infections as well as causing bone loss or prevention of bone deposition that ultimately is required to anchor the implant. 17 Evidence from laboratory-grown Pseudomonas aeruginosa biofilms suggests . The practical applications of the research include diagnostics, treatment methods, drug formulation and the use and development of medical . Bone joint infection (BJI), and especially prosthetic joint infection (PJI), represents a major public health concern (), due to: (i) their prevalence, complicating 1 to 2% of arthroplasty procedures, with an important upcoming increase due to the projected rise in prosthetic joint replacement indications in the coming years (2, 3); (ii) their severity, associated with a 5% . : Kansas State UniversityPostdoctoral: Kansas State UniversityPhone: 501-686-7958 or 501-686-5254Fax: 501-686-5359Email: smeltzermarks@uams.edu Research Description After receiving his Ph.D. from Kansas State University, Dr. Smeltzer . surements from postmortem bone tissues were performed and ap-plied to an in vitro S. aureus biofilm system (41) to assess bacterial killing and biofilm disruption using live, time-lapse imaging. Because of obvious limitations on infectious disease research in human subjects, P. aeruginosa researchers rely on a variety of in vitro and animal models. Radolf and Caimano Laboratory Research. Characterizing PLD1 Activity in Schizosaccharomyces pombe, South Eastern Regional Yeast Meeting, Memphis, TN, 2004. Working in close collaboration with Allegheny Health Network's clinicians and Carnegie Mellon faculty, the CEBR fosters the development of surgeon-scientists, physician-scientists and biomedical researchers by actively working to develop partnerships among teams of . The bone cells and the bone material that they created during the testing were made more easily recognizable by applying fluorescent stains. Periodontitis (PD) is a chronic osteolytic inflammatory disease that results in destruction of tooth-supporting structures and ultimately edentulism. Box 173980 Bozeman, MT 59717-3980 Contact: (406) 994-4770. cbeinfo@biofilm.montana.edu His work focuses on the development of antimicrobial strategies to treat and prevent biofilm implant-related infections. In 2014, Dr. Cassat joined the Vanderbilt faculty as an Assistant Professor in the Departments of Pediatrics, BME, and Pathology, Microbiology, and Immunology, where his lab studies host . The biodegradation projects focus mostly on pharmaceutical and personal care products including the antimicrobial triclosan, the pain killer ibuprofen, the insect repellant DEET, and the detergent breakdown product nonylphenol. The expected outcome of this application is to specifically identify a protective or destructive role for DCs and T cell subsets in biofilm-induced alveolar bone loss and the mechanisms involved. 7th International Workshop on the Molecular Pharmacology and Therapeutics of Bone and other Musculoskeletal Diseases. and Anna Maria Romanelli, Ph.D. Four groups of denture acrylic were evaluated, n=2. These data were used to design studies to evaluate high-dose rifampin- containing regimens in mice as compared to standard (IDSA- Co-Director of the Bone and Joint Research Lab/Assistant Professor Dr. Williams is Co-Director of the Bone and Joint Research Lab and an Assistant Professor in the Department of Orthopaedics at the University of Utah. Premier Research Labs is recognized as the world leader in cellular resonant formulations, establishing a high standard in the nutritional industry. Tian F, Kanka J, Yang F, Min J, Hammond PT, Role of siica nanoparticles in monitoring and prolonging release of drug-eluting polyelectrolyte . Here are a few examples of our leading-edge research. Introduction. Since antibiotics are designed to fight planktonic free-living bacteria, studying antibiotic resistance in biofilm communities poses a paradigm shift. We describe here clinical characteristics and bacteriological determinants of this condition.Methods: A retrospective cohort study described characteristics, outcome and determinants of treatment failure of all patients with proven Corynebacterium . October 27: Marvin Whiteley, Georgia Institute of Technology. Available equipment includes: CDC biofilm reactors, electrolysis equipment, cell and bacterial culture equipment. 590 Wakara Way. It is believed that osteitis is a nidus of inflammation and occurs more commonly in patients with refractory CRS. Secular scientists have difficulty interpreting them. The research goal of my Bone and Joint Research Laboratory is to understand the human musculo-skeletal system better, in order to aid the development of biomechanical and safe solutions for the. Our research and teaching activities cover many areas of dental research, including mechanics of polymers and polymer matrix composites, structure/property relationships in biomaterials, biomedical optics, finite element analysis, micromechanics, tribology, biomechanics of engineered tissues, electron microscopy, fracture mechanics, cardiovascular biomechanics, and image processing. According to the 2009-2014 National Health and Nutrition Examination Survey (NHANES), around 61 million adults over 30 years-old have periodontitis (42.2%) with 7.8% having severe periodontitis. In particular, our research aims to investigate the mechanisms underlying the metastatic process and the pathogenesis of inflammatory articular diseases, with a focus on the process of extravasation . Role: Principal Investigator. Our research focus on the development of a new paradigm to enable the design, synthesis and manufacturing of materials and structures from the molecular scale. 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